12/22/2023 0 Comments Hydrogen gasSome clinical investigations have also shown the beneficial effects of inhaled hydrogen gas on acute myocardial infarction and out-of-hospital cardiac arrest 4, 11. Several studies on animals have shown that the hydrogen reduces the reactive oxygen species (ROS) in tissues 1, 4, 5, 6, 8 and has other antioxidant and/or anti-inflammatory effects on ischaemia-reperfusion injury in which the ROS are produced in excess 4, 9, 10. Hydrogen gas (molecular hydrogen) has emerged as an attractive medicinal agent due to its therapeutic and preventive effects in various diseases 1, 2, 3, 4, 5, 6, 7. These results provide the fundamentals for elucidating the mechanisms underlying the in vivo favourable effects of hydrogen gas in mammalian systems. The concentration varied significantly depending on the organ ( P = 0.03). The maximum concentration was the highest in liver and the lowest in the kidney (29.0 ± 2.6 vs 18.0 ± 2.2 μmol/L P = 0.03 in all cases). P = 0.004 in all cases) and increased more gradually in muscle than in the other organs. The time to saturation was significantly longer (20.2 vs 6.3–9.4 min. The maximum concentration, time to saturation, and other measurements representing the dynamics of distribution were obtained from the concentration curves, and the results obtained for different organs were compared. The hydrogen concentration was measured in the brain, liver, kidney, mesentery fat and thigh muscle of rats. Herein, the sequential changes in hydrogen concentration in tissues over time were monitored using a highly sensitive glass microsensor and continuous inhalation of 3% hydrogen gas. Although animal and clinical studies have reported promising results, hydrogen distribution in organs after administration remains unclear. Hydrogen has therapeutic and preventive effects against various diseases.
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